HORDB

ID: hor002894
Uniprot ID: P11975
Protein name: Neuropeptide H
Gene name: NA
Organism: Cardisoma carnifex (Blue land crab)
Family: NA
Source: animal
Expression: sinus gland
Disease: NA
Comments: NA
Taxonomy: Cardisoma (genus), Gecarcinidae (family), Grapsoidea (superfamily), Thoracotremata, Eubrachyura, Brachyura (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: NA

Function: Neuropeptide H is the precursor molecule for neuropeptides C, D, E, F and I, which arise by incomplete proteolysis of neuropeptide H.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P11975-F1.pdb

hor002894_AF2.pdb

hor002894_ESM.pdb

Mass:	426747	Formula:	C153H249N47O54S
Absent amino acids:	CIKNQVWY	Common amino acids:	A
pI:	4.7	Basic residues:	4
Polar residues:	11	Hydrophobic residues:	13
Hydrophobicity:	-22.78	Boman Index:	-6199
Half-Life:	1 hour	Half-Life Yeast:	2 min
Half-Life E.Coli:	2 min	Aliphatic Index	73.61
Instability Index:	4556.39	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 3298549
Title: Amino acid sequences of neuropeptides in the sinus gland of the land crab Cardisoma carnifex: a novel neuropeptide proteolysis site.